Set in the early 2000's, the story of Ganglion follows the everyday adventures of Kenji Isobe, a professional henchman for the Ganglion Corporation, which plots world domination with evil schemes such as “Operation: Tokyo Cedar Pollen” and “Operation: Mount Fuji Detonation”. Kenji's workplace is a battlefield, where every day he has to deal with workplace drama, unreasonable bosses and crushing defeat at the hands of the hero HOPEMAN.